A Molecular Libraries Screening Center in San Diego

The San Diego Center for Chemical Genomics (SDCCG) is a multi-disciplinary, collaborative effort of scientists from the Burnham Institute for Medical Research, Torrey Pines Institute for Molecular Studies, and Human Biomolecular Research Institute. Housed at the Burnham, SDCCG is bringing the power of high throughput screening (HTS) to the public research community.  The screening of thousands of organic compounds (small molecule libraries) with HTS is one of the most powerful techniques employed in commercial drug discovery. The SDCCG was selected to be a part of the Molecular Library Screening Center Network (MLSCN) established by the NIH Roadmap for Medical Research Initiative to accelerate medical discoveries. The network allows researchers with promising assays to use the expertise and resources of the SDCCG to identify novel chemical probes and make the results available to the research community through PubChem, a shared database.

The mission of the SDCCG is to use advanced screening technologies to identify chemical probes that interact with proteins involved in cellular signaling. Optimization of these probes using chemistry and informatics will form the basis of a new generation of medicines.